The Northern Tuli Game Reserve consists of 71,173 hectares of privately-owned land, boasting the world's largest elephant population on private land. Other species that roam on the reserve include lions, leopards, cheetahs and hyenas, as well as 350 recorded bird species.
Serolo Safari Camp is bordered by the Limpopo River in the south and the Motloutse River in the east. The landscapes are diverse, ranging from riverine forests to Mopane veld to sandstone ridges. Due to this diversity, multiple habitats exist and the region is home to a variety of fauna and flora.